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At this very moment, in laboratories around the world, teams of researchers are busy fighting the war against cancer. They are identifying new drugs, new regimens and new approaches to treatment that may be of use to men with prostate cancer in the future.
Men with advanced forms of the disease are actively involved in this fight. Therapy options are limited for them and they may not be effective enough to halt the progress of cancer in their bodies. Many of them decide to volunteer to test new drugs. They realize that their bodies will respond rapidly to any potential improvements and any knowledge they discover will be vital for them and for many others to come.
Some of these trials are already causing excitement in medical circles. As we all know, chemotherapy drugs can play an important role in improving the lives of men with advanced prostate cancer. They only problem is that they often don’t distinguish between tumor cells and healthy cells. As a result, healthy cells can be killed during treatment.
Targeted therapies are being developed to avoid this common problem. These are drugs that are designed to interfere with the way cancer cells grow, with the way cancer cells interact with each other and/or with the way that the immune system interacts with the cancer. They don’t affect the rest of the body or any other cells.
None of these targeted therapies have been formally approved yet but some early studies are showing that they may be in the future. If so, it’s only a matter of time before a form of targeted chemotherapy is used that will result in much better outcomes for men with prostate cancer.
Another treatment which is in its experimental stage is interfering with cancer cell growth. All cells in the body, cancer cells included, rely on a complicated system to know when to grow, when to divide and when to die. This system depends on specialized proteins, fats and other substances which tell the different parts of the cell how and when to act. In recent years, cancer researchers have been studying ways of interfering with this system, thereby stopping the growth of cancer in its tracks.
So far, they haven’t been very successful when it comes to prostate cancer but they have made progress. As a result of their trials, they have discovered that it is often better to use a combination of different drugs to treat prostate cancer. Often, you see much better results than you would with either drug used alone.
Other researchers are working on how to interfere with cancer cell spread. As these cells start to divide and spread, new blood vessels grow on the old ones to supply the new tumor with the nutrients it needs. This process is called angiogenesis. If this could be stopped, researchers believe that the new tumor cells would die and the cancer would stop growing in the body.
There are currently several trials exploring this very theory. In 2004, the angiogenesis inhibitor bevacizumab (Avastin) was approved for use in colorectal cancer. Since then, it has been proven to help women combat breast cancer and it currently being tested for prostate cancer. Thalidomide has also been discovered to have some anti-angiogenic properties and it too is being tested in men with prostate cancer.
And that’s not all. Researchers are also trying to discover ways of harnessing the immune system to fight off cancer cells. In order for the immune system to be able to do this, it has to learn to recognize abnormal cells.
This is not so easy in the case of cancer cells because they always start out as normal healthy cells. As a result, the immune system never has an opportunity to act against them.
Researchers are trying to counter this by developing therapeutic vaccines. The hope is that in future, the immune system will learn how to recognize prostate cancer cells and fight them off before they develop.
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